刘易斯(多格雷·斯科特 Dougray Scott 饰)和妻子分开多年,工作非常繁忙的他将孩子托付给住在伦敦的父亲抚养。终于,刘易斯得了空,决定将父亲和儿子接回自己的身边,他兴高采烈的搭乘上了开往伦敦的火车。在车上,刘易斯邂逅了名为伊莲娜(琳赛·邓肯 Lindsay Duncan 饰)的女子,一来二去之间,两人还真有点碰撞出了火花的意思。 让刘易斯没有想到的是,不知从什么时候起,车内的服务人员全都失去了踪迹,更糟糕的是,这辆列车的刹车似乎失灵了。原来,在车上隐藏了一个恐怖分子,他对列车动了手脚,想要全部的乘客成为他的陪葬品。目前,只有刘易斯一个人得知这可怕的真相,全部的希望都凝聚到了他的肩上。The widow Dr. Lewis Shaler and his son Max are traveling late night by train to London. Lewis will leave Max with his grandparents to attend victims of a great accident at the hospital where he works. When Max accidentally spills coffee on the coat of the promoter Sarah Barwell, Lewis is embarrassed and offers to pay for the cleaning of her coat. Soon they start a conversation and feel attracted for each other. When the train stops, Lewis sees a man on the track apparently fixing the brakes. When the trains moves, he sees another man crawling on the tracks. Lewis seeks out the train guard and finds that he is missing. Further, the train does not stop at the stations. He tries to contact the driver that asks how many passengers are still on board and nothing else. Lewis contacts the passengers Jan Klimowski, Peter Carmichael and Elaine Middleton and they team-up expecting to stop the train. Soon they conclude that the train has no brake and the driver is a suicidal. What will happen to them?