看似和一般女生没什么区别的高中生星野春(福田沙纪 饰),实际上却有着一个巨大困扰。她是IS,即所谓的双性人。在上高中之前,她一直作为男生生活着,性格也颇像男孩。但由于户籍上填得是女生,梦想成为糕点师的星野春不得不依据学校的规定,穿上了女生的校服,做起了女孩。觉得别扭不自在的春在新学校,闹出了不少尴尬的事;结识了新朋友,同样是IS患者的相原美和子(刚力彩芽 饰);也第一次对男生,即学长伊吹宪次(井上正大 饰)脸红心跳。不知所措的春对这些心理和生理的变化,起初是排斥的态度,但在一系列事情中,春慢慢了解和接受自己…… 本剧改编自六花千代的同名漫画。该漫画获得了2007年第31回讲谈社漫画赏少女漫画部门受赏。IS follows the high school life of Hoshino Haru. Haru was born intersex meaning that he was born with physical characteristics of both sexes and cannot clearly be assigned as a binary gender based on these physical characteristics. Registered as female at birth but later raised as a boy (gender) since he always played with boys his age during the earlier years of school. Haru is forced to attend high school as a girl because of this.