查克(戴恩·库克 Dane Cook 饰)在10岁的一个游戏上,得罪了“小巫婆”。她下了一个毒咒在查理身上。成年后查理成为一名牙医,成功的事业并没有令他过得开怀——他从来没有获得过真爱,奇怪的是,追求他、和他上床的女孩非常多,然而她们总是离他而去,并且下一任的男朋友总是她们的真名天子。查克慢慢察觉到,自己只不过是一道桥,帮助别人通往真爱所在,“幸运查克”的名号也是这么来。而这一切,原来都是因为当年的魔咒。 当查理遇上凯姆(杰西卡·阿尔芭 Jessica Alba饰)并倾心爱上了她,真正的痛苦到来了。他不知道怎么做才能留住爱人,让她不再奔向下一个人。查理无微不至的宠爱凯姆,为她做饭给她送花,甚至为她约会她心仪的男生,祈求魔咒不会再应验。Early thirty-something dentist Dr. Charlie Logan has never experienced true love, despite having had a number of girlfriends over the years. After an announcement by one of his ex-girlfriends as such at her wedding, Charlie gets a reputation as being a good luck charm. Every woman he has slept with has met and married her dream man immediately following. He is encouraged to exploit this reputation by his long time best friend, Dr. Stu Klaminsky, a sex obsessed, sex starved schlub who became a plastic surgeon just so that he could masturbate over the sight of women's breasts. Charlie doesn't want to be solely a stepping stone for women, which is how they end up treating him once he gains this reputation as a lucky charm, but rather one's true love. He believes the woman of his dreams is accident-prone Cam Wexler, who works as the penguin caretaker at the aquarium. Cam initially doesn't want to date Charlie because of his reputation as a one-night stand type of guy. Charlie in turn doesn't want to sleep with Cam as he is certain she will find her true love after they do. Cam's true love seems destined to be penguin expert Howard Blaine. To get to true happiness, Charlie feels he needs to speak to Anisha Carpenter, who he feels is the cause of his current problems. Anisha ends up helping him in a way he doesn't expect.